Free Images - SnappyGoat.com- bestof:C9orf72.png en SHH gene Cytogenetic Location 9p21 2 The C9orf72 gene is located on the short p arm of chromosome 9 at position 21 2 More precisely the C9orf72

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$The Raf/MEK/ERK (MAPK) propagates growth signals in the cell. Misregulation can lead to cancer.\nThe red dots on the active EGFR are phosphorylated tyrosines. PDB entries: 1egf, 1nql, 1m17, 2jwa, 3njp, 2gs6, 1gri, 1xd2, 3ksy, 5p21, 6xi7, 6q0j, 2y4i,$

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MDM2 (violet, left side) and MDMX (red) tag p53 with ubiquitin (yellow) leading to its degradation into small peptides by a proteasome (violett). p53 prevents cancer formation and acts as a guardian of the genome. Mutations in the p53 gene contribute to about half of the cases of human cancer.

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Epidermal growth factor (EGF) activates the EGF receptor (EGFR), that dimerizes. Red dots are phosphorylated tyrosines. The signal transduction continues through GRB2/SOS, Ras, Raf/MEK and ERK, that will activate many processes in the cell.

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Free Images: "bestof:C9orf72.png en SHH gene Cytogenetic Location 9p21 2 The C9orf72 gene is located on the short p arm of chromosome 9 at position 21 2 More precisely the C9orf72"

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