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After dopamine binding, the dopamine receptor changes his shape and binds the inactive G protein.The G protein expels its GDP molecule replacing it by GTP. and falls into two pieces. The Galpha subunit binds to and activates the enzyme adenylyl cyclase, which produces then cyclic AMP spreading a signal through the cell.

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The glucagon like peptide-1 receptor (GLPr) is a G proteincoupled receptor (GPCR) that mediates the action of GLP-1, a peptide hormone. The activated receptor has a strong effect on the management of type 2 diabetes mellitus and obesity, including glucose homeostasis and regulation of gastric motility and food intake.

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A GTP-bound G-alpha protein (blue) binds to and activates the enzyme adenylyl cyclase, which produces then cyclic AMP spreading a signal through the cell.

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