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| Keywords: Malaria LifeCycle(French version).GIF Malaria Plasmodium Plasmodium vivax Plasmodium ovale Plasmodium malariae Plasmodium knowlesi malaria_LifeCycle French_version GIF Traduction en français de l ™image suivante malaria_LifeCycle GIF Life cycle of Malaria The malaria parasite life cycle involves two hosts During a blood meal a malaria-infected female Anopheles mosquito inoculates sporozoites into the human host Sporozoites infect liver cells and mature into schizonts which rupture and release merozoites Of note in P vivax and P ovale a dormant stage hypnozoites can persist in the liver and cause relapses by invading the bloodstream weeks or even years later After this initial replication in the liver exo-erythrocytic schizogony the parasites undergo asexual multiplication in the erythrocytes erythrocytic schizogony Merozoites infect red blood cells The ring stage trophozoites mature into schizonts which rupture releasing merozoites Some parasites differentiate into sexual erythrocytic stages gametocytes Blood stage parasites are responsible for the clinical manifestations of the disease The gametocytes male microgametocytes and female macrogametocytes are ingested by an Anopheles mosquito during a blood meal The parasites ™ multiplication in the mosquito is known as the sporogonic cycle While in the mosquito's stomach the microgametes penetrate the macrogametes generating zygotes The zygotes in turn become motile and elongated ookinetes which invade the midgut wall of the mosquito where they develop into oocysts The oocysts grow rupture and release sporozoites which make their way to the mosquito's salivary glands Inoculation of the sporozoites into a new human host perpetuates the malaria life cycle http //www dpd cdc gov/DPDx/HTML/ImageLibrary/ malaria_LifeCycle GIF PD-USGov Plasmodium life cycle PD-USGov CDC lifecycles | ||||
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